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KMID : 0361020110540070445
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Korean Journal of Otolaryngology - Head and Neck Surgery
2011 Volume.54 No. 7 p.445 ~ p.453
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Morphological Study of the Mouse Inner Ear
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Lee Kyu-Yup
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Abstract
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Hearing impairment is one of the most common sensory disorders in human. The major causes of sensorineural hearing loss are aging, noise, genetics, ototoxicity, and autoimmune. A better understanding of sensorineural hearing loss is required to understand the mechanisms by which specific causes lead to hearing impairment. The study of sensorineural hearing impairment in humans is limited by the inability to follow inner ear development and elucidate the true mechanism of hearing loss in human. Animal experiment is an essential part of research and testing in the life sciences. Because of the complicated structures of the inner ear, every morphological study is made to be appropriate for such a special tissue. Here I will outline the several morphological methods of the rodent inner ear covering such basic things including fixation, and sectioning.
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KEYWORD
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Immunohistochemistry, Antibody, Electron microscope, Inner ear
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